Brewitt et al.
1999
Recent randomized, double-blinded,
placebo-controlled clinical studies demonstrated and replicated
positive benefits of homeopathic recombinant human growth hormone
(Brewitt et al. 1999). The three differently designed studies
showed that an oral chewable tablet of homeopathic growth hormone
was clinically efficacious, safe, non-toxic and economically
practical as a longevity medicine. Functional benefits included
those on the physical, physiological and psychological
levels.
Good biomarkers for aging include
self-reported symptoms that impede the physical, psychological or
emotional quality of life. Self-reported quality of life measures
were evaluated in all three types of randomized, double-blinded,
placebo-controlled studies conducted on homeopathic recombinant
human growth hormone (HrhGH) (Brewitt et al. 1999). Healthy people
ages 18-72 years of age were enrolled (n=162) for four to eight
weeks in three different cities. Their exercise activity ranged
from none to at least five times per week. In one city, no one knew
the substance being evaluated. Blood chemistry, total weight, lean
body mass and body shape measurements were objective parameters
evaluated. Clinical efficacy was determined by statistical
differences between chewable tablets of HrhGH and placebo that were
self-administered three times/day.
Serum igf-1 levels
The study findings highlighted several
significant observations relevant to longevity. First, baseline
serum IGF-1 levels were, on average, lower than the mean average
reference range in two of the three cities selected for study
(P<0.0001). Neither age nor exercise lead to the normalization
of serum IGF-1 levels, only HrHGH lead to normal raises in IGF-1.
Three physicians who used exercise only to raise IGF-1 levels
actually decreased by –28 ± 4% in their serum IGF-1 levels after
the first 21 days of the study.
Oral administration of HrhGH reproducibly
increased serum IGF-1 levels by +25 ± 14% after three weeks on a
formula of 6X +12C and +21 ± 13% and +26 ± 10% on a formula of 6C +
100C +200C after three and four weeks, respectively. HrhGH was the
single most important intervention raising serum-IGF-1 levels.
Exercise without adequate nutrition decreased serum IGF-1 levels.
While serum IGF-1 has been cited most as a reliable measure of hGH
physiological activity, others do not include it as a reliable
indicator (Ho and Veldhuis 1994)
Lean body mass
Maintenance of lean body mass is critical
for longevity and quality of life functions since lean mass below
65% of ideal weight no longer supports life (Griffin et al. 1998).
Lean mass includes muscle, bone, organ density, all of which
deteriorate during the aging process and directly correlate with
death. Lean body mass reproducibly increased 2.5 ± 1.2 lbs in three
weeks on 6C +100C +200C HrhGH compared to no increase on placebo
(P=0.05). Weight loss of -3.27 ± 0.6lbs occurred on the 6X +12C
HrhGH formula and –2.07 ± 0.52 lbs occurred on the 6C + 100C +200C
HrhGH formula compared to none on placebo (P<0.05). In addition
to objectively measured gains in lean mass, subjects self-reported
gains in arm and leg strength, endurance and appearance.
Substantiation of the body weight and lean
mass changes occurred with measurable body shape changes. Upper
arms, where lean mass is most observable, increased +0.30 ± 0.1
inch in three weeks compared to placebo (P<0.0001). Neither age
nor gender affected this outcome, only HrhGH treatment. Hips, where
fat mass is commonly observable, decreased –2.1 ± 0.50 inches/month
on treatment compared to placebo (P<0.001).
Overall improvements
Twenty-five self-perceived symptoms were
evaluated in all studies. HrhGH treatment groups showed significant
improvements in those areas most specific to hGH target sites
compared to placebo. For example, in terms of hormonal declines
that affect hGH-target sites of skin, intestines, urogenital and
lungs, subjects reported statistically significant improvements in
terms of skin softness and moisture, easier breathing with less
coughing and phlegm build-up, relief from intestinal pain and/or
bloating. In terms of neurological and psychological improvements
subject reported statistically significant relief from apathy,
anxiety, anger, headaches, joint pain and/or edema. Sleep quality,
length and depth also significantly improved.
Quality of life during aging means being
able to complete the physical tasks necessary to carry out one’s
functions. Subjects on HrhGH treatment reported statistically
greater energy and endurance, increased libido and visual
improvement compared to placebo. Thus, specific target sites for
hGH in the body that can be self recognized for health symptoms
such as lungs, skin, intestines, urogenital, heart function, eyes
and brain were all reported as improved on homeopathic recombinant
hGH versus placebo.
These short clinical studies demonstrate
that intervention with a cell signaling treatment approach using
oral chewable tablets of HrhGH provided statistically significant
physiological and psychological benefits above placebo effects.
While longer studies are necessary, the implications of these
studies are that affordable and non-toxic options are available to
people as preventative medicines.
References:
Brewitt, Barbara Ph.D.Chapter 8.2
from The Advanced Guide to Longevity Medicine Published by IMPAKT
Communications 3/31/01
Brewitt, B., Hughes, J., Welsh,
E.A., Jackson, R. Homeopathic human growth hormone for physiologic
and psychologic health. Alt. Compl. Ther. 1999 5(6):373-385
Griffin, G. E., Paton, N. I.,
Cofrancesco Jr., J., Arastéh, K., Bauer, G., Schwenk, A., Mauss,
S., Mulligan, K. 1998 Nutrition and quality of life in HIV
infection. The role of growth hormone in HIV-associated wasting. J.
Clin. Res. 1:199-218
Ho, K.Y., Velduis, J.D. Diangosis
of growth hormone deficiency in adults. Endocrinol. Metab. 1994
1(suppl. A):561-563
Semsei, I. On the nature of
aging. Mech. Ageing Dev. 2000 117(1-3):93-108
