Adenosine Tri-Phosphate:

Adenosine 5'-triphosphate (ATP) is our internal source of energy and it's proper function is CRITICAL to "Thermogenesis" within the body.  ATP is a multifunctional nucleotide in the intracellular transfer of energy.   ATP consists of adenosine and three phosphate groups (triphosphate). The phosphoryl groups, starting with that on AMP (Adenosine Monophosphate), are referred to as the alpha (α), beta (β), and gamma (γ) phosphates. ATP is extremely rich in chemical energy, in particular between the second and third phosphate groups. The net change in energy of the decomposition of ATP into ADP (Adenosine Diphosate) and an inorganic phosphate is -12 kCalories / mole in vivo (inside of a living cell) and -7.3 kCalories / mole in vitro (in laboratory conditions).  This massive release in energy makes the decomposition of ATP extremely exothermic.  ATP is also one of four monomers required for the synthesis of ribonucleic acids.  ATP is used to provide the phosphate for protein kinase reactions in signal transduction pathways.

Adrenocorticotrophic Hormone:

Adrenocorticotropic hormone (ACTH or corticotropin) is a polypeptide hormone synthesised and secreted from corticotropes in the anterior lobe of the pituitary gland in response to the hormone corticotropin-releasing factor(CRF) released by the hypothalamus.  ACTH acts through the stimulation of cell surface ACTH receptors, which are primarily located on the adrenocortical cells. ACTH stimulates the cortex of the adrenal cortex gland and boosts the synthesis of corticosteroid, mainly glucocorticoids, but also, mineral-corticoids and sex steroids (androgens).  ACTH is also related to the circadian rhythm in many organisms.

Amino Acids:

An amino acid contains both amino and carboxylic acid functional groups.  An amino acid is any one of a class of simple organic compounds containing carbon, hydrogen, oxygen, one nitrogen.  These compounds are the biochemical building blocks of proteins.  They form short polymer chains called peptides or polypeptides which in turn form structures called proteins.  Each amino acid has at least one carboxyl (COOH) group, which is acidic, and one amino (NH(2)) group, which is basic.  Amino acids join together in long chains, the amino group of one amino acid linking with the carboxyl group of another.  The linkage is known as a peptide bond, and a chain of amino acids is known as a polypeptide.

Apoptosis:

Apoptosis is one of the main types of programmed cell death (PCD).  Apoptosis is carried out in an ordered process that generally confers advantages during an organism's life cycle.  For example, the differentiation of human fingers in a developing embryo requires the cells between the fingers to initiate apoptosis so that the fingers can separate.  The way the apoptotic process is executed facilitates the safe disposal of cell corpses and fragments.  Defective apoptotic processes have been implicated in an extensive variety of diseases.  Too much apoptosis causes cell-loss disorders, whereas too little results in uncontrolled cell proliferation, namely cancerous tumors.

Bio-photons:

In general scientific usage, the term bio-photon is used more specifically to denote those photons that are detected by biological probes as part of the general weak electro-magnetic radiation of living biological cells.  “Bio-photonics” is the science, research and applications of photons in their interactions within and on biological systems.  In this instance, topics of research pertain more generally to basic questions of biophysics, the regulation of biological, cell growth and differentiation, connections to so-called delayed luminescence, and spectral emissions in super-molecular processes in living tissues, etc.).  Some have speculated that they may be involved in various cell functions, such as mitosis, or even they may be produced and detected by the DNA in the cell nucleus.  These speculations have not yet resulted in a testable hypothesis.  However, one of the interesting features of bio-photons is the enormous amount of research prompted in diverse fields, including Eastern medicine, homeopathy, acupuncture, biophysics, biology and chemistry.

Borojo patinoi cuatr:

Circadian Rhythms:

Also called circadian clocks.  The human circadian clock runs to a 24-hour rhythm that regulates metabolism, cell division, and hormone production, as well as our wake-sleep cycle.  Scientists using an imaging technique called fluorescence resonance energy transfer (FRET) have discovered a six-hour clock within the 24-hour circadian clock.  "Period" and "Timeless", acts in conjunction with each in a negative feedback loop that takes about 24 hours to complete.  Two other circadian genes known as "Clock" & "Cycle" stimulate production of the “Period” & “Timeless” proteins at night, which begin to accumulate in the cell's cytoplasm.  After about six hours, the two proteins move into the nucleus; their presence turns off the genes, which then remain inactive until Period and Timeless degrade and the whole cycle begins anew.

Endocrine glands:

Endocrine System:

A system of ductless glands that secrete chemical messengers called hormones that circulate within the body via the bloodstream to affect distant organs.  Hormones act as "messengers," and are carried by the bloodstream to different cells in the body.  The endocrine system does not include exocrine glands such as salivary glands, sweat glands and glands within the gastrointestinal tract.  This field of medicine is called endocrinology.  The endocrine system links the brain to the organs that control body metabolism, growth and development, and reproduction.  Signal transduction of some hormones with steroid structure involves nuclear hormone receptor proteins that are a class of ligand activated proteins that, when bound to specific sequences of DNA serve as on-off switches for transcription within the cell nucleus.  These switches control the development and differentiation of skin, bone and behavioral centers in the brain, as well as the continual regulation of reproductive tissues.  The endocrine system regulates its hormones through negative feedback. Increases in hormone activity decrease the production of that hormone.  The immune system and other factors contribute as control factors also, altogether maintaining constant levels of hormones.

Energy Medicine:

Any of a class of medicinal disciplines that deals with illness at the root cause and bringing the body back to homeostasis.  Homeopathy, acupuncture, bio-feedback, and electromagnetic therapy are just a few examples of “Energy Medicine.”

Growth Factors:

Small proteins, produced by the body, that enable cells to communicate and coordinate activities between one another.  Growth factors bind to specific receptor sites on a cell surface.  A specific growth factor may use different signal transduction pathways at different time and with different cells.  Growth factors are an essential component in the complex feedback loops between the immune, nervous and endocrine systems, and significant effects on RNA/DNA, protein synthesis, lipid metabolism, and cell division.

Growth Hormone:

Growth hormone "hGH" is a polypeptide hormone produced in anterior lobe of pituitary gland.  hGH is a single-polypeptide chain of 191 amino acid residues and has molecular weight of about 22,000.  Growth hormone "hGH" is also called somatotropin.  hGH stimulates growth and cell reproduction in humans and other vertebrate animals.  "hGH" refers to human growth hormone but, this older abbreviation has begun to carry paradoxical connotation (see below Human Growth Hormone).  Together with human chorionic somatotropin (hCS) and prolactin (PRL) it forms a group of hormones with growth-promoting activity.  The biochemistry of hGH is complex. Under normal conditions, we all have sufficient quantities of hGH, but as we age the amount and pattern of hGH secretion changes.  Basal levels are highest in early childhood.  The amplitude and frequency of peaks is greatest during the pubertal growth spurt.  Healthy children and adolescents average about 8 peaks per 24 hours. Adults average about 5 peaks. Basal levels and the amplitude and frequency of peaks decline throughout adult life.  The main action of hGH is to stimulate the liver and other tissues to produce IGF-1(Insulin Like Growth-factor).  hGH is essential to promoting the growth of bone and muscle.  hGH increases protein synthesis, lipolysis (increases levels of free fatty acids and glycerol), influences mineral and bone metabolism and has prolactin-like activity.  hGH has powerful anabolic (muscle building) effects as well as lipotropic (breakdown and utilization of body fat) effects.  The overall result of these effects is an increase in lean tissue mass and a decrease in body fat, a process known as “Thermogenisis”.  hGH has also been shown to deter many of the effects of the aging process.  It has been scientifically proven that one of the major factors in starting the aging process is caused by a decreased production of hGH. Low hGH levels associated with visible signs and symptoms such as wrinkles, forgetfulness, unexplained weight gain, decreased sex drive, bone and joint diseases, and hair loss.  hGH controls the size of muscles and internal organs and the length of bones.  The bones of the legs and arms are lengthening in direct response to hGH until age eighteen.  These bones fuse at age eighteen.  Final height and length of bone is determined by this event, since no further lengthening is possible after this fusion.  hGH activates receptors in the brain, which results in the production of endorphins, molecules which keep one's mood even and upbeat with a profound sense of well-being.  Skin cells respond to hGH with even growth and improved elasticity.  Bone cells respond by making new bone.  And although this effect requires two or more years for completion, hGH has been shown to help reverse osteoporosis.  Fat cells are burned for energy.  hGH deficiency is responsible for that weight gain (spare tire), which is so characteristic around middle age.  Muscle cells respond to hGH by becoming larger and stronger, especially in the upper body.  The strength and endurance of youth reappears.  Many people are able to read without reading glasses again, as the ciliary muscle of the eye becomes stronger again.

Growth Hormone Regulating Hormones:

Growth hormone regulating hormones are Hypothalmic hormones that induce (somatoliberin) or inhibit (somatostatin) the release of hGH.

Growth Hormone Releasing Hormone:

(GHrh), also known as growth hormone releasing factor (GRF) is produced in the arcuate nucleus of the hypothalamus.  It stimulates the production and secretion of growth hormone "hGH" from the anterior pituitary gland, and like hGH, it is released in a pulsatile manner.  Additionally, GHRH also promotes non-REM(rapid eye movement) sleep directly.

Homeopathy:

Natural form of medicine (A.K.A. “Energy Medicine”) that uses immeasurably small doses of medicinal substances to stimulate the body’s defense mechanisms and promote the healing process.  The word homeopathy is derived from the Greek words “homeo” and “pathos” meaning “similar suffering.” The focus of homeopathy is balance or homeostasis.

Homeostasis:

Homeostasis is one of the fundamental characteristics of living things.  It is the maintenance of the internal environ-ment within tolerable limits.  All sorts of factors affect the suitability of the human body fluids to sustain life; these include properties like temperature, salinity, and acidity, and the concentrations of nutrients such as glucose, various ions, oxygen, and wastes, such as carbon dioxide and urea.  Since these properties affect the chemical reactions that keep our bodies alive, there are built-in physiological mechanisms to maintain them at desirable levels.  Optimal health or well being is the balance of mind, body and spirit.  When energies in the body are interfered with, the root cause of disease, we lose homeostasis.  Symptoms are not the cause of health problems, but rather an expression of the body’s inability to defend against disease and bring it back to homeostasis.

Homo-toxicology:

Homo-toxicology and the term homo-toxins (human poisons) are terms first coined by Dr. Hans-Heinrich Reckeweg, MD.  Homotoxicology involves the use of sarcodes, nosodes and homeopathic remedies to stimulate into action, the immune system's defense mechanisms and regulatory processes helping them to remove homotoxins from the body and returning it to homeostasis.

Hormesis:

"Hormesis" is defined as; the observations that weak concentrations of biological agents stimulate physiological activity, medium concentrations of agents depress physiological activity, and large concentrations halt physic-logical activity, the former being the foundation of homeopathy.  In contrast to homeopathy, orthodox (allopathic) medicine, seeks to treat symptoms with toxic drugs that depress or halt physiological activity and ultimately weaken the body.

Hormone:

A hormone is a chemical messenger from one cell (or group of cells) to another.  The hormones are produced by the endocrine glands in the human body.  Hormone molecules are secreted directly into the bloodstream (however, some hormones, called ectohormones, are secreted to the outside environment).  The function of hormones is to serve as a signal to the target cells; the action of hormones is determined by the pattern of secretion and the signal transduction of the receiving tissue.  Hormone actions vary widely, but can include stimulation or inhibition of growth, induction or suppression of apoptosis (programmed cell death), activation or inhibition of the immune system, regulating metabolism and preparation for a new activity (e.g., fighting, fleeing, mating, etc.) or phase of life (e.g., puberty, caring for offspring, Menopause, etc.).  In many cases, one hormone may regulate the production and release of other hormones.  Many of the responses to hormone signals can be described as serving to regulate metabolic activity of an organ or tissue.  Hormones also control the reproductive cycle of virtually all multi-cellular organisms.  The rate of production of a hormone is often regulated by a homeostatic control system, generally by negative feedback.

Hormone secretion can be stimulated and inhibited by:

Vertebrate hormones fall into four chemical classes:

Human Growth Hormone "hGH":

The term "hGH" was used in research to differentiate between human somatotrophic extracts or synthetically built somatotropin and animal derived extracts.  Because it is well known that animal extracts do not have the same physiological activity and can cause a wide array of side effects, they are no longer used in human therapies.  Recombinant hGH is now required by the FDA in order to avoid the neuro-degenerative dangers of pituitary glandular source material (raw extracts).

Human placental lactogen (HPL):

Its structure is related to that of human growth hormone (hGH) and together with Prolactin (PCL) forms a group of hormones that have growth promoting properties.  HPL increases production of insulin and IGF-1.  HPL induces lipolysis with the release of free fatty acids.  With fasting and release of HPL, free fatty acids become available for use as fuel.

Insulin Growth Factors:

Produced in the body, IGF’s polypeptides have considerable sequence similarity to insulin.  The growth potentiating effects of IGF-I and IGF-II are modulated by a family of six insulin-like growth factor binding proteins (IGFBPs).  Although both IGF receptors are present in adult human adrenocortical cells, the steroidogenic effect of IGF-II is mediated through the IGF-I receptor, which only binds to the IGF-I receptor.  IGF-II stimulates basal secretion from adult human adrenocortical cells more potently and is less growth hormone "hGH" dependant than IGF-I.  Both IGF-I and IGF-II predominantly stimulate androgen biosynthesis.  IGF-I is active at the neuromuscular junction, where nerve and muscle cells interact.  The tissues most associated with IGF are muscle, cartilage, bone, liver, nerves, skin, and lungs.

Interleukin 1:

Interleukin-1 (IL-1) is a cytokine that is secreted by macrophages, monocytes and dendritic cells.  It is an important part of the inflammatory response of the body against infection.  It increases the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes, the cells that fight pathogens, to the site of infection.  It also re-sets the hypothalamus thermoregulatory center, leading to an increased body temperature which expresses itself as fever.  It is therefore called an endogenous pyrogen.  The increased body temperature helps the body's immune system to fight infection.  Some people experience a mild "healing crisis" something similar to this process for a few days when beginning the Bio-Plene program.  It has been described as “Flu-like” symptoms without the fever.

Nanotechnology:

Nanotechnology is any technology which exploits phenomena and structures that can only occur at the nanometer scale, usually 0.1 to 100 nm (1/1,000 µm, or 1/1,000,000 mm) which is the scale of several atoms and small molecules.  A possible way to interpret this size is to take the width of a hair, and imagine something ten thousand times smaller.  Nanoscience and nanotechnology are an extension of the field of materials science, and materials science departments at universities around the world in conjunction with physics, mechanical engineering, bioengineering, and chemical engineering departments are leading the breakthroughs in nanotechnology.  The related term nanotechnology is used to describe the interdisciplinary fields of science devoted to the study of nanoscale phenomena employed in nanotechnology.  Nanoscience is the world of atoms, molecules, macromolecules, quantum dots, and macromolecular assemblies, and is dominated by surface effects such as Van der Waals force attraction, hydrogen bonding, electronic charge, ionic bonding, covalent bonding, hydrophobicity, hydrophilicity, and quantum mechanical tunneling, to the virtual exclusion of macro-scale effects such as turbulence and inertia.

Pituitary gland:

The pituitary gland is an endocrine gland about the size of a pea, at the base of the brain.  The pituitary gland secretes hormones regulating a wide variety of bodily activities, including “trophic” hormones that stimulate other endocrine glands and is itself, regulated by releasing hormones from the hypothalamus.  The pituitary gland is divided into two sections: the anterior lobe and the posterior lobe.  Its posterior lobe is connected to a part of the brain called the hypothalamus.  The anterior pituitary lobe receives releasing hormones from the hypothalamus via a portal vein system.  The posterior pituitary is, in effect, a projection of the hypothalamus.  It does not produce its own hormones, but only stores and releases the hormones oxytocin and ant diuretic hormone (ADH).  The anterior pituitary secretes growth hormone (hGH), prolactin, follicle-stimulating hormone, eternizing hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, endorphins and other hormones.  It functions in response to chemical signals from the hypothalamus, including TRH (hydrotropic-releasing hormone), CRH (corticotropin-releasing hormone), DA (dopamine, "prolactin inhibiting factor"/PIF), GnRH (gonadotropin-releasing hormone), and GHRH (growth hormone releasing hormone).  These hormones from the hypothalamus cause release of the respective hormone from the pituitary. For example, TRH releases TSH, CRH releases ACTH, etc.  The control of release of hormones from the pituitary is in a negative feedback loop.

Precursor:

A substance from which another, usually a more mature or biologically active substance is formed.

Principle of Similars, the:

“Like cures like.” Homeopathy or “Energy Medicine” is based on “Resonance” (A.K.A. “the principle of similars").  Basic principles of physics teach us that hypersensitivity exists when there is resonance.  Organisms commonly experience a biphasic response to various stimuli. In other words, extremely small doses of a substance exhibit different and sometimes opposite effects than what they cause in high concentrations.  In orthodox medicine, vaccines represent the most closely related example of treatment, to the “Principle of Similars”.

Recombinant DNA Technology:

Growth Hormone "hGH" is a 191 amino acid chain with its own specific DNA sequence. Microbiologists have developed a method for naturally linking the sugars, proteins and phosphates to build DNA that are bio-identical to the body’s.  This DNA sequence for growth hormone "hGH" is inserted into simple organisms.  Once they “recombine”, these natural and bio-identical molecules are removed from the growth medium and prepared for a wide array of uses.  Our bodies recognize and respond to this growth hormone molecule just as if it had been produced endogenically.  Recombinant growth hormone "hGH" is the safest form.

Resonance:

In physics, resonance is the tendency of a system to absorb more energy when the frequency of the oscillations matches the system's natural frequency of vibration (its resonant frequency) than it does at other frequencies.  In the human body, wavelength energy resonates at the molecular and cellular levels and beyond.  Cellular chemical messengers carry complex energy information and holographic instructions to new molecular and cellular structures.  Energy medicine then, seeks to restore and/or maintain proper resonance.

Sesquiterpene Lactones:

Sesquiterpene Lactones are secondary metabolytes found in some plants.  They are found rather abundantly in Borojoa p.  According to the National Cancer Institute:  "Sesquiterpene lactones may have anti-inflammatory and anticancer effects. Plants containing Sesquiterpene lactones have been used in some cultures to treat certain medical problems."  http://www.cancer.gov/dictionary/?CdrID=330182

Secretagogue:

Secretagogues are substances that induce secretions from cells. Certain peptides induce gastric and pancreatic secretions.  Some OTC products contain secretagogues designed to stimulate the production of hGH within the body, which may cause hGH producing glands to be stressed or overworked and therefore, speed up the process of the aging of those glands.  It is our belief that the body works best on its' own when in proper resonance.

Somatomedins:

Insulin-like peptides (the IGF groups) are somatomedins.  They are made in the liver and their production is stimulated by growth hormone "hGH".

Somatostatin:

Somatostatin is a mixture of two peptides, one built of 14 amino acids, the other of 28.  Somatostatin is secreted by cells of the hypothalamus, pancreas, and by so called delta cells of stomach, intestine.  The actions of the hormone are inhibitory.

Somatostatin's main actions are:

·         Inhibit the release of growth hormone "hGH"

·         Inhibit the release of thyroid-stimulating hormone (TSH)

·         Suppress the release of gastrointestinal hormones

·         Prolong gastric emptying, gall bladder contraction and intestinal motility

·         Suppress the release of pancreatic hormones

·         Inhibit the release of insulin

·         Inhibit the release of glucagon

·         Suppress the exocrine secretatory action of pancreas

Somatostatin antagonizes the effects of Growth Hormone Releasing Hormone (GHRH)

Somatotrophin:

Growth Hormone "hGH", somatotropin. (See Growth Hormone above)

Supplements(Growth Hormone):

Bio-Plene™ is NOT a supplement and is not designed or intended to be.  To be sure, there is no OTC HGH oral spray that has any significant amount of hGH.  OTC hGH supplemental sprays can contain not more than 2000ng of hGH.  The average prescription dose or injection of GH would be more in the neighborhood of 20,000ng. to have any effect.  Additionally, hGH is bio-active for only about 15 or 20 minutes.  And an excessive amount of hGH supplementation has its own associated and well documented set of side effects.  The human body, when in resonance, is quite capable of producing and restoring appropriate levels of hGH, as necessary.  Bio-Plene is designed to restore proper resonance within the mechanisms of the anti-aging processes.  (*See the Clinical Information Section)

Thermogenesis:

"Thermo" means heat. "Genesis" means create.  Thermogenesis is food-to-fuel conversion.  When you burn fat through thermogenesis you become leaner.  Obviously what we eat has a lot to do with what we see.  And the lack of exercise compounds the problem.  But the other major factor in thermogenesis is how much the fat management process slows down with aging, particularly after forty.  It is highly probable that the "spare tire" many people experience is caused by a thermogenic defect.  Thermogenesis is not a cure.  It is a physiological process, like digestion, which can enhance what God has already given to us.  Restoration of Thermogenesis is paramount to fat loss and inch reduction.

Thermo-luminescence:

Thermoluminescence is a physical method used to understand the action mechanism of homeopathic remedies.  Thermoluminescence is a property of all solids emitting light after irradiation and heating; it is usually used for archaeological dating.  Researchers have frozen a dynamized homeopathic solution in order to "fix" it, and then they irradiate it and reheat it.  By comparing the thermoluminescence of the homeopathic dilution to that of neutral water, they were able to see the "defects" of the ice structure. The results of this experiment show:

• that a homeopathic dilution differs from water without question.
• that different dilution levels give water different characteristics.

Researching bio-photons can give a possible physical explanation to the therapeutic properties of homeopathic medicines.

Thryoid Stimulating Hormone (TSH):

Thyroid Stimulating Hormone (TSH) is a hormone synthesised and secreted by hydrotropic cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland.  TSH stimulates the thyroid gland to secrete the Hormones thyroxin (T4) and triiodothyronine (T3).  The production of TSH is inhibited by the production of somatostatin by the hypothalamus.  T3 and T4 also inhibit TSH production and secretion, creating a regulatory negative feedback loop.

Thyrotropin-releasing hormone:

Thyrotropin-releasing hormone (TRH) is a tripeptide hormone that stimulates the release of TSH (thyroid-stimulating hormone) and prolactin the anterior pituitary.  TRH is produced by the hypothalamus and travels to the pituitary via The pituitary portal system.  In addition to the brain, TRH can also be detected in other areas of the body including the gastrointestinal system and pancreatic islets.

Transcription factor:

In molecular biology, a transcription factor is a protein that binds DNA at a specific promoter or enhancer region or site, where it regulates transcription. Transcription factors can be selectively activated or deactivated by other proteins, often as the final step in signal transduction.

Trophic Hormones:

Hormones that stimulate the hormone production of other endocrine glands.

Tumor Necrosis Factor (TNF):

Tumor necrosis factor-alpha (TNFα, cachexin or cachectin) is an important cytokine involved in systemic inflammation and the acute phase response.  TNFα is released by white blood cells, endothelium and several other tissues in the course of damage, e.g. by infection.